WebABSTRACT Atkamine is a complex marine pyrroloiminoquinone alkaloid that comprises a heptacyclic scaffold bearing five different heterocycles and four contiguous stereocenters, and therefore it is a highly challenging target for synthetic chemists.We herein reported a modular synthetic strategy toward this alkaloid, featuring a formal [5+2] annulation and … WebThree new cyclic peptides, euryjanicins B (2), C (3), and D (4), have been isolated from the Puerto Rican marine sponge Prosuberites laughlini, and the structures were elucidated by chemical degradation, ESIMS/MS, and extensive 2D NMR methods. When tested against the National Cancer Institute 60 tumor cell line panel, all of the purified isolates displayed …
Total syntheses of makaluvamines A, B, C, D and E, cytotoxic ...
WebNov 1, 2024 · a, Representative examples of pyrroloiminoquinone-type natural products (also called pyrroloquinolines). The part of the structures shown in red highlight the atoms that probably derive from Trp. Web批注本地保存成功，开通会员云端永久保存 去开通 borehole records scotland
Synthesis of the Marine Pyrroloiminoquinone Alkaloids, …
WebNational Center for Biotechnology Information WebApr 21, 2010 · Manynatural products with biologically interesting structures have been isolated from marine animals and plants such as sponges, corals, worms, etc. Some of them are discorhabdin alkaloids. The discorhabdin alkaloids (discorhabdin A-X), isolated from marine sponges, have a unique structure with azacarbocyclic spirocyclohexanone and … WebMar 1, 1993 · The structure determination of the new compounds are reported and preliminary evidence for the ability of this class of metabolites to inhibit the function of mammalian topoisomerase 119 and to inhibits the growth of human ovarian tumor in an athymic mouse model is reported. We present the isolation and characterization of seven … borehole micro pub stone