Inbreeding in mice
WebAt commercial suppliers or in controlled breeding colonies, inbred mice are rederived from archived stock every five to ten generations, greatly reducing genetic drift and inbreeding … WebJan 4, 2016 · Inbreeding in allogamic organisms bring the deleterious recessive alleles to homozygosity; the immediate consequence is an increase in the frequency of defective offspring, or, in another words, an increase in the genetic load of the population. This phenomenon is called inbreeding depression or inbreeding degeneration.
Inbreeding in mice
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WebVariation in response to fescue toxicosis was examined in inbred and linecross mice. In Exp. 1, exposure to a 50% endophyte-infected tall fescue diet (E+) reduced ADG of males from six inbred lines, but ADG of males from one line was modestly higher on E+. Lines differed (P < .01) for reproductiv … http://ko.cwru.edu/info/breeding_strategies_manual.pdf
WebDec 10, 2007 · Mouse populations are known to persist at high densities for extended periods of time (Bronson 1979), and during population outbreaks house mice are subject to inbreeding (Sutherland et al. 2005). Therefore, because there are significant fitness consequences of inbreeding in mice ( Margulis 1998 ; Meagher et al. 2000 ), selection … WebDec 13, 2024 · To provide further context for our estimates of nucleotide diversity (π), we also retrieved recently published diversity metrics from house mice in the Collaborative Cross (Srivastava et al. 2024), various inbred and wild-caught mouse colonies (Salcedo et al. 2007), and inbred and wild-caught rats (Smits et al. 2004; Ness et al. 2012).
http://www.informatics.jax.org/greenbook/chapters/chapter2.shtml WebApr 7, 2002 · Clutton-Brock TH. Female transfer and inbreeding avoidance in social mammals. Nature. 1989 Jan 5; 337 (6202):70–72. [Google Scholar] DeChiara TM, Efstratiadis A, Robertson EJ. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature. 1990 May 3; 345 …
WebMouse Breeding Recommendations 1. Keep accurate breeding records. Make a pedigree for each transgenic founder or embryonic stem cell-mouse chimera. 2. Mate mice when they are sexually mature (6 to 8 weeks old). We recommend that transgenic founders or chimeras be mated to C57BL/6 mice.
WebInbreeding serves to retain and pass on the good points in a particular family of animals, while eliminating the bad. When animals are inbred (particularly close brother/sister … some like it hot articleWebNational Center for Biotechnology Information some like it hot backgroundWebInbred Mice Inbred mouse strains are defined as colonies produced by a minimum of 20 generations of brother-sister mating, traceable to a single founding pair. This mating … some like it hot behind the scenesWeb1.1.2 Inbreeding. Inbreeding is defined as the probability of two alleles in an individual being identical by descent, and is normally the result of mating related individuals. The rate of inbreeding is a function of the characteristics of the foundation stock as well as limited population sizes in subsequent generations (Falconer, 1989 ). some like it hot band new orleansWebOct 27, 2005 · Like inbred mouse strains, outbred mouse stocks have an official definition: “a closed population (for at least four generations) of genetically variable animals that is bred to maintain maximum ... small business relief fund bostonWebAn inbred strain is one that: is produced using at least 20 consecutive generations of sister x brother or parent x offspring matings, or; is traceable to a single ancestral pair in the 20th … some like it hot broadway cast recordingWebThe progeny of such matings are called "inbred-derived" to distinguish them from inbred mice. Obviously the mated mice should have recent common ancestors within an inbred line if the genetic variance is to be kept low. In terminal experiments requiring large numbers of mice from a single strain, inbred-derived mice may be superior to inbred ... small business relief grant 2.0