Cisplatin research
WebCisplatin is a potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF- α -induced apoptosis. Technical Data M.Wt: 300.05 Formula: Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need alternative therapy options. Researchers at...
Cisplatin research
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WebCisplatin is also sometimes used to treat head and neck cancer (including cancer of the mouth, lip, cheek, tongue, palate, throat, tonsils, and sinuses), lung cancer, cancer of the … WebMay 1, 2005 · Cisplatin is a chemotherapeutic drug used in conjunction with IR to treat various types of cancer, including cervical carcinoma as well as head and neck cancers ( 2, 3 ). Although the mechanism of cisplatin sensitization to IR remains largely undefined, evidence suggests that the NHEJ pathway is involved ( 4, 5 ).
WebOct 11, 2024 · Defining the mechanisms by which cisplatin enters hair cells remains challenging, as cisplatin can enter cultured cells (see Figure 3A) across the cell membrane via passive diffusion ( Hall et al., 2008 ). In zebrafish neuromasts, hair cells with functional TMC1 channels (see Figure 3B) are more susceptible to cisplatin-induced cytotoxicity ... WebSep 3, 1991 · After a preliminary dose-finding study involving 12 patients with advanced or locally recurrent head and neck cancer, 27 patients were treated on a phase II protocol, using fluorouracil 350 mg/m2/d by continuous intravenous (IV) infusion over 5 days, followed on the sixth day by a 2-hour IV infusion of cisplatin 50 mg/m2, administered during the …
WebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck … WebThe researchers found that when they applied an electric current through platinum electrodes in a continuous culture chamber containing E. coli bacteria, a reaction occurred in which the supposedly inert platinum metal (Pt 0) of the electrodes was oxidized to form both platinum (II) (Pt 2+) and platinum (IV) (Pt 4+ ).
WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in …
WebAnchoring aspirin onto cisplatin could create a cancer treatment capable of overcoming drug resistance in cisplatin resistant cells, new research shows. Cisplatin, along with other chemotherapeutic drugs, is used to treat various types of cancer, including testicular, ovarian, lung and bladder cancer. However, clinical use of cisplatin is ... hilde hotels costa ricaWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … hilde jones super holiday toursWebIntroduction: The aim of this multicenter phase II trial was to evaluate the combination of oral vinorelbine and cisplatin with radiotherapy (RT) after cisplatin-docetaxel induction chemotherapy (CT) in patients with locally advanced non-small cell lung cancer (NSCLC). Patients and methods: Patients with previously untreated, inoperable, histologically or … smallwood c of e primary academyWebMay 1, 2006 · Abstract and Figures Cisplatin is currently one of the most widely used anticancer drugs in the world. The unlikely events surrounding the discovery of its anticancer activity, subsequent... hilde knops notarisWebJan 14, 2024 · Chemotherapy Always Benefits the Cancer Center. Cancer centers significantly mark up chemotherapy drugs, which I cover in the article The Absurd Markup of Over 300% on Average For Chemotherapy Drugs. It is always very profitable for the chemotherapy center when the patient agrees to use Cisplatin. Due to the margins … hilde lindemann holding and letting goWebcisplatin It is a treatment for a number of different types of cancer. How GC works These chemotherapy drugs destroy quickly dividing cells, such as cancer cells. How you have … smallwood camshaftWebCisplatin is a chemotherapy drug that contains the metal platinum. It stops or slows growth of cancer cells and other cells that grow rapidly by damaging their DNA. FDA Approved … smallwood camper sales